The difference is not simply scale. It is architectural and commercial.
A mainframe room was generally built around one organisation’s hardware. Power, cooling and floor layout could all be designed for a particular machine or family of machines. Replacing the system could make much of the surrounding environment redundant.
Modern data centres are much more hardware-neutral. One facility can support x86 servers, ARM-based systems, storage platforms, network equipment and, in some cases, mainframes alongside one another, with the building providing the resilient physical platform rather than dictating the hardware that runs inside it.
Ownership changed just as significantly.
Early computer centres were internal cost centres. The organisation using the computing equipment generally owned and operated the room around it.
Colocation separated those responsibilities. An organisation could retain control of its own hardware while using a specialist provider for the facility, power, cooling, physical security and connectivity around it.
That change is central to the history of colocation. The client no longer needs to build a data centre simply to control its own infrastructure.
Modern colocation has continued to develop from there. The facility still matters, but so do the operational services around it: engineering support, service management, migration planning, connectivity and the people responsible for keeping the environment visible once equipment is deployed.
Instead of every organisation duplicating power, cooling, security and connectivity infrastructure internally, these capabilities can be shared within a purpose-built facility, enabling tenants to benefit from the economies of scale, industry influence and specialist expertise that dedicated operators provide.